Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation

Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation

Abstract Background Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cells (PRPCs) offers potential for vision restoration. However, substantial...

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Main Authors: Raghavi Sudharsan, Natalia Dolgova, Jennifer Kwok, Alexa Gray, Yu Sato, Agustin Luz Madrigal, Praveen Joseph Susaimanickam, Emil Kriukov, Petr Baranov, John H. Wolfe, Gustavo D. Aguirre, David M. Gamm, William A. Beltran
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Photoreceptor precursor cells
Retinal transplantation
Retinal degenerative diseases
Metabolic stress
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s13287-025-04509-w
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https://doi.org/10.1186/s13287-025-04509-w

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