Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling

Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately impacts Black women and has limited effective therapeutic options. Consequently, there is an urgent need to develop novel approaches for the treatment of TNBC. Previously, we identified monopolar spin...

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Bibliographic Details
Main Authors: Kassidy M. Jungles, Caroline R. Bishop, Cydnee M. Wilson, Meilan Liu, Kalli R. Jungles, Kari Wilder-Romans, Corey W. Speers, Lori J. Pierce, James M. Rae
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Monopolar spindle kinase I
Radiotherapy
Radiosensitization
Type I interferon
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000697
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