Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing

Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing

Abstract Breast cancer (BRCA) is a common malignant tumor, and its immune microenvironment plays a crucial role in disease progression. In this research, we utilized single-cell RNA sequencing and bulk RNA sequencing technologies, combined with in vivo and in vitro experiments, to thoroughly investi...

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Bibliographic Details
Main Authors: Sixuan Wu, Baohong Jiang, Zhimin Li, Yuanbin Tang, Lunqi Luo, Wenjie Feng, Yiling Jiang, Yeru Tan, Yuehua Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Breast Cancer Research
Subjects:
BRCA
FOLR2+ macrophages
CD8+ T cells
CXCL9-CXCR3 axis
Single-cell RNA sequencing
Immune microenvironment
Online Access:https://doi.org/10.1186/s13058-025-01980-4
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https://doi.org/10.1186/s13058-025-01980-4

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