Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Abstract Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. Here, combining computational ranking and functional determination, we identify the transmembrane protein Plexin-B2 (PLXNB2) as one of the top molecular...

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Main Authors: Emma Schuster, Nurmaa K. Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew D. Hoffman, Reta Birhanu Kitata, Golam Kibria, Youbin Zhang, Joshua R. Squires, Chunlei Zheng, Erika Ramos, Rokana Taftaf, David Scholten, Hannah F. Almubarak, Valery Adorno-Cruz, David P. Sullivan, Carolina Reduzzi, Allegra C. Minor, William Purev-Ochir, Sabina Spahija, Rong Xu, Kalliopi P. Siziopikou, Leonidas C. Platanias, Ami Shah, William A. Muller, William J. Gradishar, Massimo Cristofanilli, Chia-Feng Tsai, Tujin Shi, Huiping Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62862-z
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https://doi.org/10.1038/s41467-025-62862-z

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