TARGETING GROUP A STREPTOCOCCUS WITH A RECOMBINANT CHIMERIC VACCINE: INTEGRATING SCPA AND SPEA FRAGMENTS

TARGETING GROUP A STREPTOCOCCUS WITH A RECOMBINANT CHIMERIC VACCINE: INTEGRATING SCPA AND SPEA FRAGMENTS

AbstractObjective: To develop a vaccine against group A streptococci (Streptococcus pyogenes, GAS), the causative agent of a broad spectrum of infections with varying severity.Methods: The expression vectors pET27 and pQE30 were utilized to clone genes encoding recombinant proteins, which were subse...

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Main Authors: Nadezhda Vladlenovna Duplik, Galina Fedorovna Leontieva, Tatiana Anatolievna Kramskaya, Kseniya Petrovna Bogatireva, Tatiana Vitalievna Gupalova, Elena Alekseevna Bormotova, Irina Vladimirovna Koroleva, Alexander Nikolaevich Suvorov
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2019-08-01
Series:Медицинская иммунология
Subjects:
group a streptococcus (s. pyogenes, gas)
c5a peptidase (scpa)
exotoxin spea
recombinant chimeric vaccine
immunogenicity
protectivity.
Online Access:https://www.mimmun.ru/mimmun/article/view/3138
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