The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing

The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing

Abstract The epithelial sodium channel (ENaC) is essential for osmoregulation in tetrapod vertebrates. There are four ENaC-subunits (α, β, γ, δ) which form αβγ- or δβγ-ENaCs. While αβγ-ENaC is a ‘maintenance protein’ controlling sodium homeostasis, δβγ-ENaC might represent a ‘stress protein’ monitor...

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Main Authors: Fynn Zahnow, Chiara Jäger, Yassmin Mohamed, Gianluca Vogelhuber, Fabian May, Alexandra Maria Ciocan, Arianna Manieri, Stephan Maxeiner, Gabriela Krasteva-Christ, Oskar Schnappauf, Matthew R. D. Cobain, Lars Podsiadlowski, José Luis Crespo-Picazo, Daniel García-Párraga, Mike Althaus
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08436-7
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https://doi.org/10.1038/s42003-025-08436-7

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