Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions

Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles, a process tha...

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Main Authors: Weiqi Li, Chunting Wu, Xinyu Zhou, Xinhui Huang, Chunmei Zhang, Yongjie Ma, Jinqiu Hu, Xiaoyan Bi, Junyu Ma, Mengyao Li, Dong Lu, Liang Hu, Jiahua Fan, Fuli Ya
Format: Article
Language:English
Published: Tsinghua University Press 2025-07-01
Series:Food Science and Human Wellness
Subjects:
platelet activation
cd36
hyperlipemia
sulforaphane
broccolis
camp/pka pathway
nox2
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250165
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