Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

Microglia are brain-resident macrophages playing pivotal roles in central nervous system (CNS) development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance remains largely unknown. Here, by utilizing a visible conditional knockout allele of pu.1/spi1b gene (the...

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Bibliographic Details
Main Authors: Yi Wu, Weilin Guo, Haoyue Kuang, Xiaohai Wu, Thi Huong Trinh, Yuexin Wang, Shizheng Zhao, Zilong Wen, Tao Yu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
pu.1 dosage
microglia
turnover
maintenance
cell competition
Online Access:https://elifesciences.org/articles/105788
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https://elifesciences.org/articles/105788

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