tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway

tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway

Abstract Background Recurrent spontaneous abortion (RSA) affects approximately 1–5% of childbearing women and poses a significant threat to global reproductive health. Transfer RNA-derived small RNAs (tsRNAs) are a novel class of noncoding RNAs implicated in various human diseases. However, the role...

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Main Authors: Jialyu Huang, Jiawei Wang, Shuang Wang, Xiangpeng Xiong, Ruiyin Jiang, Chaoyi Xiong, Lu Wang, Lingling Huang, Yan Zhao, Zheng Fang, Xiaoyan Ai, Jiaying Lin
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
Recurrent spontaneous abortion
Trophoblast
tRF-5028c
CRKL
Rap1
Online Access:https://doi.org/10.1186/s11658-025-00706-w
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https://doi.org/10.1186/s11658-025-00706-w

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