Design, synthesis, biological evaluation and molecular docking study of thiadiazole-isatin hybrid analogues as potential anti-diabetic and anti-bacterial agents

Design, synthesis, biological evaluation and molecular docking study of thiadiazole-isatin hybrid analogues as potential anti-diabetic and anti-bacterial agents

We have synthesized thiadiazole-isatin hybrid analogues (1–20), characterized through different spectroscopic techniques such as 1HNMR, 13CNMR, HREI-MS, and evaluated against α-glucosidase and α-amylase enzymes. All analogues showed potent inhibitory potentials, having an IC50 values ranged from 22....

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Main Authors: Ghadah Aleid, Shahzad Ahmad Abbasi, Hayat Ullah, Reda Abdel-Hameed, Asmaa Hegazy, Gul Mehnaz, Eshraqa Ali, Sumayyah Al-Marshedy, Anoud AlShammari, Fazal Rahim, Hidayat Ullah Khan, Shoaib Khan, Rashid Iqbal, Zeeshan Niaz, Muhammad Taha
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Results in Chemistry
Subjects:
Synthesis
α-amylase
α-glucosidase
Antibacterial
Thiadiazole
SAR and molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624005010
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