NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes

NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes

Abstract NAMPT is an important intracellular metabolic enzyme (iNAMPT) regulating the NAD+ salvage pathway. However, increased cellular stress (infection, inflammation, hypoxia) promotes the secretion of extracellular NAMPT (eNAMPT), a TLR4 ligand and damage-associated molecular pattern protein (DAM...

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Bibliographic Details
Main Authors: Marisela Rodriguez, Haifei Xu, Annie Hernandez, Julia Ingraham, Jason Canizales, Fernando Teran Arce, Sara M. Camp, Skyler Briggs, Aikseng Ooi, James M. Burke, Jin H. Song, Joe G.N. Garcia
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
eNAMPT
DAMP
Gasdermin D
Ubiquitination
NLRP3 inflammasome
Pyroptosis
Online Access:https://doi.org/10.1186/s12964-025-02164-5
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https://doi.org/10.1186/s12964-025-02164-5

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