Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats

Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats

Background: Neuroinflammation in the frontal cortex and hippocampus is the key contributor in the pathogenesis of neurodegenerative diseases. Lipopolysaccharide (LPS) is a bacterial endotoxin (E-coli phenol extract) used to induce the neuroinflammation in animal models. Our study is aimed to study t...

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Bibliographic Details
Main Authors: Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Amit Massand, Chettiar Ganesh Kumar, Teresa Joy, Melisha Michael D souza, B.V. Murlimanju
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Translational Research in Anatomy
Subjects:
Metformin
Morphological and microscopic findings
Neuroinflammatory diseases
Neuroprotective agent
Online Access:http://www.sciencedirect.com/science/article/pii/S2214854X2400089X
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