Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-dependent mechanisms with unknown possible therapeutic applications...

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Bibliographic Details
Main Authors: Apiwan Arinno, Pichayapa Sukmak, Purisha Kulworasreth, Thaniya Sricharunrat, Chutima S. Vaddhanaphuti, Pawin Pongkorpsakol
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Gallic acid
Colitis
Tight junction
Intestinal barrier function
Myosin light-chain kinase (MLCK)
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257125000112
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