Evaluation of pharmacokinetics and relative bioavailability of pentoxifylline and its metabolite in beagle dogs following different formulations

A single-oral-dose, two-period cross-over study with a 5-day washout period under fed condition was conducted in six beagle dogs to explore the pharmacokinetic characteristics and relative bioavailability between sustained-release (SR) tablets and enteric-coated (EC) tablets of pentoxifylline (PTX)...

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Bibliographic Details
Main Authors: Yuxiang Xu, Hongxin Qie, Haopeng Zhao, Wenlin Gong, Peiyuan Wang, Xiaonan Gao, Jinglin Gao, Zhangying Feng, Mingxia Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1488076/full
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