Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Abstract The vasodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rabbit eyes, an ocular hypertension (OHT) rat model, and cultured human neuron-like cells. Blood flow in the optic nerve head (ONH) was measured using laser speckle flowgraphy following i...

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Main Authors: Takazumi Taniguchi, Takahiro Akaishi, Tatsuya Hata, Rieko Yamashita, Yoshihiko Esaki, Ryo Morofuji, Komei Okabe, Masahiro Fuwa, Yasuko Yamamoto, Li Guo, Soyoung Choi, Vy Luong, Takashi Ota, Najam A. Sharif, M. Francesca Cordeiro, Masaaki Kageyama
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Glaucoma
Calcium channel blocker
Felodipine
Retinal ganglion cells
Ocular blood flow
Neuroprotection
Online Access:https://doi.org/10.1038/s41598-025-09733-1
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https://doi.org/10.1038/s41598-025-09733-1

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