Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
The complexity of a common inflammatory disease is influenced by multiple genetic and environmental factors contributing to the susceptibility of disease. Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 in...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/846782 |
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| _version_ | 1832563099942518784 |
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| author | G. V. Paramel A. Sirsjö K. Fransén |
| author_facet | G. V. Paramel A. Sirsjö K. Fransén |
| author_sort | G. V. Paramel |
| collection | DOAJ |
| description | The complexity of a common inflammatory disease is influenced by multiple genetic and environmental factors contributing to the susceptibility of disease. Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 inflammasome. The multimeric NLRP3 complex results in the caspase-1 activation and the release of potent inflammatory cytokines, like IL-1β. Several studies have been performed on the association of the genetic alterations in genes encoding NLRP3 and CARD8 with the complex diseases with inflammatory background, like inflammatory bowel disease, cardiovascular diseases, rheumatoid arthritis, and type 1 diabetes. The aim of the present review is therefore to summarize the literature regarding genetic alterations in these genes and their association with health and disease. |
| format | Article |
| id | doaj-art-81c13890377d4143a9f8b251ef1f327c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-81c13890377d4143a9f8b251ef1f327c2025-02-03T01:21:00ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/846782846782Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and DiseaseG. V. Paramel0A. Sirsjö1K. Fransén2Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, 701 82 Örebro, SwedenDepartment of Clinical Medicine, School of Health and Medical Sciences, Örebro University, 701 82 Örebro, SwedenDepartment of Clinical Medicine, School of Health and Medical Sciences, Örebro University, 701 82 Örebro, SwedenThe complexity of a common inflammatory disease is influenced by multiple genetic and environmental factors contributing to the susceptibility of disease. Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 inflammasome. The multimeric NLRP3 complex results in the caspase-1 activation and the release of potent inflammatory cytokines, like IL-1β. Several studies have been performed on the association of the genetic alterations in genes encoding NLRP3 and CARD8 with the complex diseases with inflammatory background, like inflammatory bowel disease, cardiovascular diseases, rheumatoid arthritis, and type 1 diabetes. The aim of the present review is therefore to summarize the literature regarding genetic alterations in these genes and their association with health and disease.http://dx.doi.org/10.1155/2015/846782 |
| spellingShingle | G. V. Paramel A. Sirsjö K. Fransén Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease Mediators of Inflammation |
| title | Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease |
| title_full | Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease |
| title_fullStr | Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease |
| title_full_unstemmed | Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease |
| title_short | Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease |
| title_sort | role of genetic alterations in the nlrp3 and card8 genes in health and disease |
| url | http://dx.doi.org/10.1155/2015/846782 |
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