Diverging effects of tumor necrosis factor inhibitors and conventional synthetic disease-modifying antirheumatic drugs on immunosenescence and inflammageing in rheumatoid arthritis: a cross-sectional analysis

Diverging effects of tumor necrosis factor inhibitors and conventional synthetic disease-modifying antirheumatic drugs on immunosenescence and inflammageing in rheumatoid arthritis: a cross-sectional analysis

Abstract Background Immunosenescence is characterized by a decline in naive T cells, a reduced T cell receptor repertoire, and the accumulation of terminally-differentiated and unspecifically-activated proinflammatory cells, a process called inflammageing. Premature immunosenescence is thought to be...

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Bibliographic Details
Main Authors: Tobias Schwarz, Giovanni Almanzar, Sebastian Völkl, Martin Feuchtenberger, Johannes Leierer, Christian Schmidt, Frank Deininger, Hans-Peter Tony, Marc Schmalzing, Martina Prelog
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Immunity & Ageing
Subjects:
Rheumatoid arthritis
Immunosenescence
Inflammageing
Tumor necrosis factor inhibitor
Conventional synthetic disease-modifying antirheumatic drug
Online Access:https://doi.org/10.1186/s12979-025-00508-w
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https://doi.org/10.1186/s12979-025-00508-w

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