Prostate cancer cell-derived exosomes inhibit macrophage phagocytosis through EIF3B-mediated exosomal sorting of miR-100-5p

Prostate cancer cell-derived exosomes inhibit macrophage phagocytosis through EIF3B-mediated exosomal sorting of miR-100-5p

Abstract Exosomes play significant roles in the tumor microenvironment (TME). In particular, some exosomal microRNAs (miRNAs) have the ability to mediate macrophage polarization. However, the mechanism underlying the selective enrichment of miRNAs into exosomes remains largely unknown. Herein, we co...

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Bibliographic Details
Main Authors: Yanyan Zhang, Yinying Hu, Hongyan Guo, Min Zhao, Shiqi Liu, Jing Liu, Yanqin Huang, Zhigang Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Prostate cancer
Exosome
miRNA-100-5p
EIF3B
Macrophage
Online Access:https://doi.org/10.1038/s41598-025-11799-w
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https://doi.org/10.1038/s41598-025-11799-w

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