Engineering Caffeic Acid O‐Methyltransferase for Efficient De Novo Ferulic Acid Synthesis

ABSTRACT Ferulic acid is a high‐value chemical synthesized in plants. The ferulic acid biosynthesis is still affected by the insufficient methylation activity of caffeic acid O‐methyltransferase (COMT). In this study, we engineered COMT from Arabidopsis thaliana to match caffeic acid, and the mutant...

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Main Authors: Huai Qi Shang, Qing Bo Yang, Shan Qiang, Rong Zheng, Chao Qun Zhang, Ching Yuan Hu, Qi Hang Chen, Yong Hong Meng
Format: Article
Language:English
Published: Wiley-VCH 2025-04-01
Series:Engineering in Life Sciences
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Online Access:https://doi.org/10.1002/elsc.70018
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