Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology

Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology

A growing body of literature has identified periodontal disease among the modifiable risk factors for Alzheimer's disease (AD), but the mechanisms underlying this relationship is unknown. This study investigated this relationship using a ligature-induced preclinical periodontitis (Pd) model in...

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Main Authors: Daniela M. Jimenez-Harrison, Michael J. Butler, Haanya Ijaz, Rami Alsabbagh, Menaz N. Bettes, James W. DeMarsh, Sabrina E. Mackey-Alfonso, Stephanie M. Muscat, Bryan D. Alvarez, Jade A. Blackwell, Ashton Taylor, Jeferson Jantsch, Andrew A. Sanchez, Sarah B. Peters, Ruth M. Barrientos
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Brain, Behavior, & Immunity - Health
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625000274
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