Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages

Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages

During liver injury, intrahepatic macrophage compartment is augmented by circulating monocytes that infiltrate the liver driven by C–C motif chemokine ligand/C–C motif chemokine receptor (CCL/CCR) axis including CCL1‒CCR8 axis, thereby contributing to liver inflammation. Numerous small molecular rec...

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Bibliographic Details
Main Authors: Eline Geervliet, Sahil Arora, Dagmara Donohue, Carlos Antonio de Albuquerque Pinheiro, Leon W.M.M. Terstappen, Richard Schasfoort, Julieta Paez, Raj Kumar, Ruchi Bansal
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
CCL1‒CCR8 axis
Intrahepatic monocyte infiltration and differentiation
Liver inflammation
CCR8 antagonizing peptide
In silico molecular docking
In vitro chemotaxis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000942
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