Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy synergy between CARM1 inhibition and IMiDs

Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy synergy between CARM1 inhibition and IMiDs

Advancements in the treatment of multiple myeloma (MM) have resulted in an improvement in the survival rate. However, there continues to be an urgent need for improved therapies. The protein arginine methyltransferase, CARM1 (coactivator associated arginine methyltransferase 1), is emerging as a pot...

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Bibliographic Details
Main Authors: Wei Ni, Swati Garg, Basudev Chowdhury, Martin Sattler, Dana Sanchez, Chengcheng Meng, Taisei Akatsu, Katherine A. Donovan, Jun Qi, Michelle Y. Wang, Cara Ann Starnbach, Xiaoxi Liu, Maria Tarazona Guzman, Wei Pin Teh, Richard Stone, James D. Griffin, Sara Buhrlage, Ellen Weisberg
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
multiple myeloma
MM
immunomodulatory drugs
IMiDs
CARM1
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000219
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