KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling

KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling

Abstract High-grade serous ovarian cancer (HGSOC) is a highly aggressive gynecologic malignancy, and chemoresistance remains a major challenge in its treatment. This study identifies ZDHHC8 as a key regulator of chemotherapy sensitivity in HGSOC. Bioinformatics analysis revealed that elevated ZDHHC8...

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Bibliographic Details
Main Authors: Zhuowei Xue, Xiao Li, Wanzhen Zhou, Yincheng Teng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
High-grade serous ovarian cancer (HGSOC)
Chemotherapy sensitivity
ZDHHC8
KLF5
Β-catenin signaling
Online Access:https://doi.org/10.1038/s41598-025-11845-7
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https://doi.org/10.1038/s41598-025-11845-7

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