The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases

The ubiquitin–proteasome system (UPS) plays a pivotal role in determining protein fate, regulating signal transduction, and maintaining cellular homeostasis. Protein ubiquitination, a key post-translational modification, is orchestrated by the sequential actions of three primary enzymes, ubiquitin-a...

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Bibliographic Details
Main Authors: Qian Cheng, Zuyin Li, Yongjian Li, Lei Chen, Dingbao Chen, Jiye Zhu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
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Online Access:https://www.mdpi.com/2227-9059/13/5/1082
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