Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration

Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration

An ultrasound-responsive silk fibroin (SF)-graphene oxide (GO)-based hydrogel (SF/GO-gel) was created in this study to facilitate the sustained delivery of troxerutin (Trox) in order to alleviate intervertebral disc degeneration (IDD). The SF/GO-gel@Trox system exhibited exceptional biocompatibility...

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Bibliographic Details
Main Authors: Youfeng Guo, Xiao Liu, Chao Wang, Shuguang Wang, Yufeng Huang, Shuo Ding, Zeyu Wang, Feng Wang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Intervertebral disc degeneration
Ultrasound-responsive drug delivery system
Graphene oxide
Silk fibroin
Hydrogel
Troxerutin
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007197
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