Cytolethal distending toxin from Glaesserella parasuis induces ferroptosis in porcine alveolar macrophages and mice

Cytolethal distending toxin from Glaesserella parasuis induces ferroptosis in porcine alveolar macrophages and mice

Abstract Glaesserella parasuis cytolethal distending toxin (GpCDT) is a bacterial genotoxin whose main action is to activate DNA damage responses, induce cell cycle arrest, and induce the apoptosis of host cells. In our previous studies, we reported that cells incubated with GpCDT exhibited changes...

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Bibliographic Details
Main Authors: Shiyu Xu, Li Lei, Zhen Yang, Yu Wang, Senyan Du, Qin Zhao, Xiaobo Huang, Sanjie Cao, Rui Wu, Yiping Wang, Qigui Yan, Yiping Wen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Veterinary Research
Subjects:
Glaesserella parasuis
GpCDT
ferroptosis
Online Access:https://doi.org/10.1186/s13567-025-01520-0
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https://doi.org/10.1186/s13567-025-01520-0

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