Hyperbaric oxygen therapy for ulcerative colitis patients hospitalized for moderate to severe flares (HBOT-UC): study protocol for a multi-center, randomized, double-blind, sham-controlled trial

Hyperbaric oxygen therapy for ulcerative colitis patients hospitalized for moderate to severe flares (HBOT-UC): study protocol for a multi-center, randomized, double-blind, sham-controlled trial

Abstract Background Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis. Hyperbaric oxygen therapy involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. It reduces systemic and local inflammation and up-re...

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Bibliographic Details
Main Authors: Lauren B. Bonner, Charlotte Sadler, Peter Lindholm, Denise M. Scholtens, Parambir S. Dulai, on behalf of the HBOT-UC Consortium
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Trials
Subjects:
Ulcerative colitis
Hyperbaric oxygen therapy
Randomized trial
Study protocol
Online Access:https://doi.org/10.1186/s13063-025-08932-5
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https://doi.org/10.1186/s13063-025-08932-5

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