Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma
Abstract Pleural mesothelioma (PM) is an aggressive, asbestos-linked cancer with limited treatment options and a poor prognosis. Lactate dehydrogenase B (LDHB) converts lactate to pyruvate, and its silencing reduces mitochondrial metabolism, particularly nucleotide synthesis. However, whether and a...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-08-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-025-00571-4 |
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