Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair

Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair

The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanoparticle/hydrogel hybrid system that can achieve the combined and s...

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Bibliographic Details
Main Authors: Xiaojun Li, Zeyue Sun, Xiushuai Shang, Liuting Chen, Xiaofeng Shi, Wei Xu, Shaotian Fu, Qingling He, Qihao Liang, Jie Ma, Xin Sun, Jiaju Lu, Wenjie Jin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
Injectable hydrogel
Nanoparticles
Sequential release
Immunomodulation
Osteogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424004356
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http://www.sciencedirect.com/science/article/pii/S2590006424004356

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