An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

Abstract Next-generation vaccines are essential to address the evolving nature of SARS-CoV-2 and to protect against emerging pandemic threats from other coronaviruses. These vaccines should elicit broad protection, provide long-lasting immunity and ensure equitable access for all populations. In thi...

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Main Authors: Claudio Counoupas, Elizabeth Chan, Paco Pino, Joshua Armitano, Matt D. Johansen, Lachlan J. Smith, Caroline L. Ashley, Eva Estapé, Jean Troyon, Sibel Alca, Stefan Miemczyk, Nicole G. Hansbro, Gabriella Scandurra, Warwick J. Britton, Thomas Courant, Patrice M. Dubois, Nicolas Collin, V. Krishna Mohan, Philip M. Hansbro, Maria J. Wurm, Florian M. Wurm, Megan Steain, James A. Triccas
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01144-7
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https://doi.org/10.1038/s41541-025-01144-7

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