Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts.

Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts.

Lactaptin, the proteolytic fragment of human milk kappa-casein, induces the death of various cultured cancer cells. The mechanisms leading to cell death after lactaptin treatment have not been well characterized. In this study the in vivo and in vitro effects of a recombinant analogue of lactaptin (...

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Bibliographic Details
Main Authors: Olga A Koval, Anastasiya V Tkachenko, Alexandr S Fomin, Dmitry V Semenov, Anna A Nushtaeva, Elena V Kuligina, Eugeny L Zavjalov, Vladimir A Richter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093921&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093921&type=printable

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