Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show that in mouse embryonic fibroblasts, MFN2 suppresses RhoA ac...
Saved in:
| Main Authors: | Yueyang Wang, Lee D Troughton, Fan Xu, Aritra Chatterjee, Chang Ding, Han Zhao, Laura Pulido Cifuentes, Ryan B Wagner, Tianqi Wang, Shelly Tan, Jingjuan Chen, Linlin Li, David Umulis, Shihuan Kuang, Daniel M Suter, Chongli Yuan, Deva Chan, Fang Huang, Patrick W Oakes, Qing Deng |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-09-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/88828 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells
by: Jeewon Lim, et al.
Published: (2024-12-01) -
Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
by: Eun Hee Ahn, et al.
Published: (2025-01-01) -
Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway
by: Vida Maksimoska, et al.
Published: (2025-07-01) -
Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney
by: Percin Pazarci, et al.
Published: (2024-10-01) -
Rho-GTPases subfamily: cellular defectors orchestrating viral infection
by: Beibei Zhang, et al.
Published: (2025-05-01)