Enhanced Tumor‐Targeted Delivery of Arginine‐Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis

Enhanced Tumor‐Targeted Delivery of Arginine‐Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis

Abstract Peptide‐based drugs hold great potential for cancer treatment, and their effectiveness is driven by mechanisms on how peptides target cancer cells and escape from potential lysosomal entrapment post‐endocytosis. Yet, the mechanisms remain elusive, which hinder the design of peptide‐based dr...

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Main Authors: Minghai Ma, Xing Li, Minxuan Jing, Pu Zhang, Mengzhao Zhang, Lu Wang, Xiao Liang, Yunzhong Jiang, Jianpeng Li, Jiale He, Xinyang Wang, Min Lin, Lei Wang, Jinhai Fan
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
arginine‐rich peptides
integrin β1
piezo1
positive feedback loop
tumor‐targeted delivery
Online Access:https://doi.org/10.1002/advs.202409081
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https://doi.org/10.1002/advs.202409081

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