Development of circular AAV cargos for targeted seamless insertion with large serine integrases

Development of circular AAV cargos for targeted seamless insertion with large serine integrases

Recent advancements in gene insertion have shifted from DNA-repair-dependent mechanisms to more precise approaches, enhancing safety and predictability for editing outcomes. Integrase-mediated programmable genomic integration (I-PGI) utilizes a DNA cargo to insert transgenes in a targeted, unidirect...

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Main Authors: Brett J.G. Estes, Nisha Gandhi, Jessica R. Von Stetina, Dev Paudel, Angela X. Nan, Parth Amin, Joshua Rose, Shuai Wu, Kangni Zheng, Yijun Zhang, Jesse C. Cochrane, Jonathan D. Finn, Jenny Xie
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
LSR
LSI
gene insertion
integrase
AAV
liver
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000853
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