LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitin‒proteasome degradation of p53
Abstract The Hedgehog (Hh) pathway plays critical roles in regulating appropriate tissue morphogenesis and organ formation in the gastrointestinal tract, and its dysregulation has been closely linked to the malignant progression of colorectal cancer. However, the underlying mechanisms are poorly und...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07817-4 |
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