Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing

ABSTRACT Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is preferred compared to the free mycelia...

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Bibliographic Details
Main Authors: Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis
Format: Article
Language:English
Published: Wiley-VCH 2025-03-01
Series:Engineering in Life Sciences
Subjects:
cytotoxicity testing
fungal cultivation
fungal growth
pellet morphology
protease inhibitor
Online Access:https://doi.org/10.1002/elsc.70012
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https://doi.org/10.1002/elsc.70012

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