SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Abstract Metastatic cancer, the primary cause of cancer mortality, frequently exhibits heightened dependence on certain transcription factors (TFs), which serve as master regulators of oncogenic signaling yet are often untargetable by small molecules. Selective Cell in ORgan Targeting (SCORT) nanopa...

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Bibliographic Details
Main Authors: Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
HoxB13
mechanistic insights into therapeutic action
metastatic prostate cancer
SCORT‐Cas13d nanotherapy
SCORT nanoparticles
undruggable oncogenic transcription factors
Online Access:https://doi.org/10.1002/advs.202417605
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https://doi.org/10.1002/advs.202417605

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