Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations

Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations

Abstract Background Avian influenza virus (AIV), a zoonotic pathogen found worldwide, includes multiple subtypes, one of which is the H4 subtype frequently detected in wild birds and poultry. Despite its prevalence, research on H4 subtype AIV has been scarce, with a focus predominantly on the H4N2 a...

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Main Authors: Xiaobin Peng, Xianxian Wen, Jing Deng, Mengyuan Yuan, Yang Liu, Yunqiu Zhou, XuBin Du, Han Yang, Guangqun Jiang, Xumei Li, Feng Yin, Ping Liu, Yun Tang, Zhangping Tan, Zhen Yu, Shuang Chen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
Avian influenza virus
Novel H4N1 subtype
Zoonotic potential
Public health
One health
Online Access:https://doi.org/10.1186/s12985-025-02736-4
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https://doi.org/10.1186/s12985-025-02736-4

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