Autophagy in Immune-Related Renal Disease
Autophagy is an important biology process, central to the maintenance of biology process in both physiological and pathological situations. It is regarded as a “double-edged sword”—exerting both protective and/or detrimental effects. These two-way effects are observed in immune cells as well as rena...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5071687 |
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| _version_ | 1832564692915060736 |
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| author | Xin Ye Xu-jie Zhou Hong Zhang |
| author_facet | Xin Ye Xu-jie Zhou Hong Zhang |
| author_sort | Xin Ye |
| collection | DOAJ |
| description | Autophagy is an important biology process, central to the maintenance of biology process in both physiological and pathological situations. It is regarded as a “double-edged sword”—exerting both protective and/or detrimental effects. These two-way effects are observed in immune cells as well as renal resident cells, including podocytes, mesangial cells, tubular epithelial cells, and endothelial cells of the glomerular capillaries. Mounting evidence suggests that autophagy is implicated in the pathological process of various immune-related renal diseases (IRRDs) as well as the kidney that underwent transplantation. Here, we provide an overview of the pathological role of autophagy in IRRDs, including lupus nephritis, IgA nephropathy, membrane nephropathy, ANCA-associated nephritis, and diabetic nephropathy. The understanding of the pathogenesis and regulatory mechanisms of autophagy in these renal diseases may lead to the identification of new diagnostic targets and refined therapeutic modulation. |
| format | Article |
| id | doaj-art-808fe8fc9ab24ba88b4a927ddc14aa4a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-808fe8fc9ab24ba88b4a927ddc14aa4a2025-02-03T01:10:22ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/50716875071687Autophagy in Immune-Related Renal DiseaseXin Ye0Xu-jie Zhou1Hong Zhang2Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, ChinaRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, ChinaAutophagy is an important biology process, central to the maintenance of biology process in both physiological and pathological situations. It is regarded as a “double-edged sword”—exerting both protective and/or detrimental effects. These two-way effects are observed in immune cells as well as renal resident cells, including podocytes, mesangial cells, tubular epithelial cells, and endothelial cells of the glomerular capillaries. Mounting evidence suggests that autophagy is implicated in the pathological process of various immune-related renal diseases (IRRDs) as well as the kidney that underwent transplantation. Here, we provide an overview of the pathological role of autophagy in IRRDs, including lupus nephritis, IgA nephropathy, membrane nephropathy, ANCA-associated nephritis, and diabetic nephropathy. The understanding of the pathogenesis and regulatory mechanisms of autophagy in these renal diseases may lead to the identification of new diagnostic targets and refined therapeutic modulation.http://dx.doi.org/10.1155/2019/5071687 |
| spellingShingle | Xin Ye Xu-jie Zhou Hong Zhang Autophagy in Immune-Related Renal Disease Journal of Immunology Research |
| title | Autophagy in Immune-Related Renal Disease |
| title_full | Autophagy in Immune-Related Renal Disease |
| title_fullStr | Autophagy in Immune-Related Renal Disease |
| title_full_unstemmed | Autophagy in Immune-Related Renal Disease |
| title_short | Autophagy in Immune-Related Renal Disease |
| title_sort | autophagy in immune related renal disease |
| url | http://dx.doi.org/10.1155/2019/5071687 |
| work_keys_str_mv | AT xinye autophagyinimmunerelatedrenaldisease AT xujiezhou autophagyinimmunerelatedrenaldisease AT hongzhang autophagyinimmunerelatedrenaldisease |