Metformin and chloroquine enhanced the efficacy of cytarabine in acute lymphoblastic leukemia cell lines: a drug repositioning approach

Metformin and chloroquine enhanced the efficacy of cytarabine in acute lymphoblastic leukemia cell lines: a drug repositioning approach

Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Despite advances in the treatment of ALL, high disease recurrence and the impact of chemical toxicity on patients’ quality of life persist. Drug repositioning has been proven to have antitumor and anti-inflammatory prop...

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Main Authors: Ahmad Moradi Poodeh, Gholamreza Anani Sarab, Mojtaba Pouresmaeili Ravari, Mahsa Najafzadeh, Hossein Safarpour, Asghar Zarban, Mahtab Sayadi, Seyed Mehdi Sajjadi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Acute lymphoblastic leukemia
Chloroquine
Cytarabine
Drug repositioning
Metformin
NALM-6
Online Access:https://doi.org/10.1038/s41598-025-01574-2
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https://doi.org/10.1038/s41598-025-01574-2

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