Single-cell RNA-seq analysis of mouse carotid artery under disturbed flow and human carotid plaques identifies key cell populations in atherosclerosis development

Single-cell RNA-seq analysis of mouse carotid artery under disturbed flow and human carotid plaques identifies key cell populations in atherosclerosis development

Abstract Atherosclerosis tends to occur in regions of disturbed blood flow. This study explored how disturbed flow aggravates atherosclerosis using single-cell RNA-seq (scRNA-seq) datasets from mouse carotid arteries under disturbed flow and human carotid artery plaques. The scRNA-seq datasets were...

Full description

Saved in:
Bibliographic Details
Main Authors: Xuyang Liu, Xu Li, Xin Wang, Jiawei Zhao, Chen Liu, Shaochi Wang, Zongping Xia, Yuming Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Atherosclerosis
Carotid plaque
Disturbed flow
Single-cell RNA-seq
Senescence
Fibroblast
Online Access:https://doi.org/10.1038/s41598-025-07395-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-07395-7

Similar Items