Synthesis and evaluation of novel thiohydantoin derivatives for antidiabetic activity using in silico in vitro and in vivo methods

Synthesis and evaluation of novel thiohydantoin derivatives for antidiabetic activity using in silico in vitro and in vivo methods

Abstract Diabetes mellitus remains a global health challenge, necessitating the development of novel therapeutic agents. In this study, a series of thiohydantoin derivatives (FP1–FP7) were synthesized and evaluated for their in silico, in vitro, and in vivo antidiabetic potential. Molecular docking...

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Bibliographic Details
Main Authors: Asma Bukhari, Humaira Nadeem, Iqra Zulfiqar, Maira Anwar, Syed Muzzammil Masaud, Babar Murtaza
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Thiohydantoin derivatives
Α-glucosidase inhibition
Α-amylase inhibition, molecular docking
In vivo antidiabetic evaluation
SAR analysis
Lipid profile
Online Access:https://doi.org/10.1038/s41598-025-13538-7
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https://doi.org/10.1038/s41598-025-13538-7

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