Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc--GSH-GPX4 signaling pathway

Zearalenone induces intestinal damage and flora disturbance in rats by triggering ferroptosis via the system Xc--GSH-GPX4 signaling pathway

Zearalenone (ZEA) is a mycotoxin commonly found in contaminated grains. The colon, a primary site of ZEA exposure, serves as a barrier to prevent its systemic entry. Ferroptosis signaling in intestinal epithelial cells is associated with increased intestinal inflammation. However, the role of ferrop...

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Bibliographic Details
Main Authors: Bingxin Huangfu, Jie Li, Tongxiao Xu, Xinxin Ren, Ruiqi Zhang, Yanan Chen, Jiantang Wang, Kunlun Huang, Xiaoyun He
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Zearalenone
Ferroptosis
Colon damage
Inflammation
Intestinal flora
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009455
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