Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction

ABSTRACT Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics. Tripartite motif containing 65 (TRIM65)...

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Main Authors: Tao Chen, Yang Zhang, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang, Shibiao Chen, Yong Li
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:MedComm
Subjects:
acute kidney injury (AKI)
mitochondrial dysfunction
tripartite motif containing 65 (TRIM65)
ubiquitination
voltage‐dependent anion channel 1 (VDAC1)
Online Access:https://doi.org/10.1002/mco2.70149
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https://doi.org/10.1002/mco2.70149

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