JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation

JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation

Abstract Disease tolerance is a key defense mechanism that limits damage to the host without directly reducing pathogen levels. In malaria, these mechanisms are essential for preventing severe disease and death but remain poorly understood. In this study, we show that glucocorticoid receptor (GR)-me...

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Main Authors: Fran Prenen, Leen Vandermosten, Sofie Knoops, Emilie Pollenus, Hendrik Possemiers, Pauline Dagneau de Richecour, Giorgio Caratti, Christopher Cawthorne, Sabine Vettorazzi, Yevva Cranshoff, Dominique Schols, Sandra Claes, Christophe M Deroose, Uwe Himmelreich, Jan Tuckermann, Philippe E Van den Steen
Format: Article
Language:English
Published: Springer Nature 2025-07-01
Series:EMBO Molecular Medicine
Subjects:
Glucocorticoid Receptor
Hypoglycemia
Malaria
Ruxolitinib
Tolerance
Online Access:https://doi.org/10.1038/s44321-025-00264-w
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https://doi.org/10.1038/s44321-025-00264-w

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