Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication.

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication.

The genomes of positive-sense RNA viruses encode polyproteins that are essential for mediating viral replication. These viral polyproteins must undergo proteolysis (also termed polyprotein processing) to generate functional protein units. This proteolysis can be performed by virally-encoded protease...

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Bibliographic Details
Main Authors: Danielle M Pierce, Frazer J T Buchanan, Fraser L Macrae, Jake T Mills, Abigail Cox, Khadijah M Abualsaoud, Joseph C Ward, Robert A S Ariëns, Mark Harris, Nicola J Stonehouse, Morgan R Herod
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011529&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011529&type=printable

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