Downregulating LKB1 in bone marrow mesenchymal stem cells could inhibit CD4+ T cell proliferation via the PD-1/PD-L1 signaling pathway

Background: Our previous research has shown that LKB1 in amniotic mesenchymal stem cells (MSCs) serves as a vital regulator of regulatory T cell differentiation and T cell proliferation, which may have a similar role in bone marrow MSCs (BMMSCs). Therefore, we investigated the role of LKB1 in BMMSCs...

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Bibliographic Details
Main Authors: Yaqin Zhang, Jingyi Ren, Zhongxian Liao, Xiaoyu Li, Chunying Zhang, Bihan Huang, Yingping Cao, Jiadi Chen
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Immunobiology
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Online Access:http://www.sciencedirect.com/science/article/pii/S0171298524000743
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