A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages

A single-cell transcriptomic map of the murine and human multiple myeloma immune microenvironment across disease stages

Abstract Background The long-term effectiveness of immunotherapies against Multiple Myeloma (MM) remains elusive, demonstrated by the inevitable relapse in patients. This underscores the urgent need for an in-depth analysis of the MM tumor-immune microenvironment (TME). Hereto, a representative immu...

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Main Authors: Emma Verheye, Daliya Kancheva, Hatice Satilmis, Niels Vandewalle, Rong Fan, Pauline M. R. Bardet, Emile J. Clappaert, Kevin Verstaen, Ann De Becker, Karin Vanderkerken, Kim De Veirman, Damya Laoui
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Hematology & Oncology
Subjects:
Multiple myeloma progression
5T33MM immune microenvironment
Single-cell RNA-sequencing
Human-mouse comparison
Anti-CD40 agonist therapy
Online Access:https://doi.org/10.1186/s13045-024-01629-3
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https://doi.org/10.1186/s13045-024-01629-3

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