<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy

<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy

Membrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads to inhibition of proliferation, reduction of cytokine production, cytotoxic response, and apoptosis of T lymphocytes. The cells of many tumors, regardles...

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Bibliographic Details
Main Authors: A. A. Pinevich, N. L. Vartanyan, L. N. Kiseleva, I. I. Bode, I. Yu. Krutetskaya, A. V. Kartashev, V. E. Makarov, T. E. Poneza, I. V. Smirnov, M. P. Samoilovich
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2023-06-01
Series:Медицинская иммунология
Subjects:
glioblastoma
pd-l1
pd-l2
resistant cells
fotemustine
temozolomide
gamma knife
fractionated irradiation
a172
t98g
t2
r1
Online Access:https://www.mimmun.ru/mimmun/article/view/2693
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