PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD
The purpose of this study was to investigate the relationship between childhood chronic stress(CCS), Protein kinase C beta (PRKCB) methylation and adolescent major depressive disorder (MDD). After recruiting 100 adolescents with MDD and 50 healthy controls (HCs), we evaluated the severity of CCS. PR...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2408159 |
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| author | Yuanmei Tao Meijiang Jin Hang Zhang Maojia Ran Hanmei Xu Shoukang Zou Fang Deng Lijuan Huang Hong Zhang Xiaolan Wang Yanping Wang Huijin Hou Shufang Liang Xiaohong Ma Li Yin |
| author_facet | Yuanmei Tao Meijiang Jin Hang Zhang Maojia Ran Hanmei Xu Shoukang Zou Fang Deng Lijuan Huang Hong Zhang Xiaolan Wang Yanping Wang Huijin Hou Shufang Liang Xiaohong Ma Li Yin |
| author_sort | Yuanmei Tao |
| collection | DOAJ |
| description | The purpose of this study was to investigate the relationship between childhood chronic stress(CCS), Protein kinase C beta (PRKCB) methylation and adolescent major depressive disorder (MDD). After recruiting 100 adolescents with MDD and 50 healthy controls (HCs), we evaluated the severity of CCS. PRKCB methylation was assessed by pyrosequencing using whole blood-derived DNA. To explore the relationship between CCS, PRKCB and adolescent MDD, we conducted correlation analysis and regression analysis, and constructed multiplicative interaction models and generalized linear models. PRKCB methylation and CCS were both found to be associated with MDD, and CCS was associated with PRKCB methylation. No significant CCS-PRKCB methylation interactions were observed. However, we found the interaction of CCS and MDD on PRKCB methylation. Our results found that PRKCB methylation was influenced by CCS and the disease itself, and PRKCB methylation was significantly positively associated with MDD severity, suggesting that PRKCB methylation may be a potential biomarker for adolescent MDD. This study is a cross-sectional observational study, which cannot draw the conclusion of causality. Prospective cohort studies are needed to further examine the relationship between CCS, adolescent MDD, and PRKCB methylation. |
| format | Article |
| id | doaj-art-803e7cb69e9345b9830cc828a98ddb6e |
| institution | OA Journals |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-803e7cb69e9345b9830cc828a98ddb6e2025-08-20T02:30:41ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2408159PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDDYuanmei Tao0Meijiang Jin1Hang Zhang2Maojia Ran3Hanmei Xu4Shoukang Zou5Fang Deng6Lijuan Huang7Hong Zhang8Xiaolan Wang9Yanping Wang10Huijin Hou11Shufang Liang12Xiaohong Ma13Li Yin14Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaThe purpose of this study was to investigate the relationship between childhood chronic stress(CCS), Protein kinase C beta (PRKCB) methylation and adolescent major depressive disorder (MDD). After recruiting 100 adolescents with MDD and 50 healthy controls (HCs), we evaluated the severity of CCS. PRKCB methylation was assessed by pyrosequencing using whole blood-derived DNA. To explore the relationship between CCS, PRKCB and adolescent MDD, we conducted correlation analysis and regression analysis, and constructed multiplicative interaction models and generalized linear models. PRKCB methylation and CCS were both found to be associated with MDD, and CCS was associated with PRKCB methylation. No significant CCS-PRKCB methylation interactions were observed. However, we found the interaction of CCS and MDD on PRKCB methylation. Our results found that PRKCB methylation was influenced by CCS and the disease itself, and PRKCB methylation was significantly positively associated with MDD severity, suggesting that PRKCB methylation may be a potential biomarker for adolescent MDD. This study is a cross-sectional observational study, which cannot draw the conclusion of causality. Prospective cohort studies are needed to further examine the relationship between CCS, adolescent MDD, and PRKCB methylation.https://www.tandfonline.com/doi/10.1080/15592294.2024.2408159Adolescent MDDchildhood chronic stressPRKCBDNA methylation |
| spellingShingle | Yuanmei Tao Meijiang Jin Hang Zhang Maojia Ran Hanmei Xu Shoukang Zou Fang Deng Lijuan Huang Hong Zhang Xiaolan Wang Yanping Wang Huijin Hou Shufang Liang Xiaohong Ma Li Yin PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD Epigenetics Adolescent MDD childhood chronic stress PRKCB DNA methylation |
| title | PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD |
| title_full | PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD |
| title_fullStr | PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD |
| title_full_unstemmed | PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD |
| title_short | PRKCB methylation: a potential biomarker of MDD with childhood chronic stress, a cross-sectional study in drug-naive, first-episode adolescent MDD |
| title_sort | prkcb methylation a potential biomarker of mdd with childhood chronic stress a cross sectional study in drug naive first episode adolescent mdd |
| topic | Adolescent MDD childhood chronic stress PRKCB DNA methylation |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2408159 |
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